Efecto de Una Intervención Intensiva Multimodal Sobre Los Patrones Epigenéticos de Resiliencia En Adolescentes Con Experiencias Adversas

Adverse childhood experiences are associated with long-lasting consequences on mental and physical health, underscoring the need for effective interventions to mitigate these effects. In this study, a secondary in silico approach is used to analyze how a one-week intensive multimodal intervention can positively influence epigenetic patterns of resilience in adolescents with adverse experiences. Genomic DNA methylation data from a public database (GSE164056, n=143) were used to identify Epigenetic Patterns of Resilience to Social Anxiety (PERAS), and subsequently, changes in these markers were evaluated in an independent cohort of Colombian adolescents (n=44) before and after an intensive group intervention. The results reveal significant modifications in specific CpG sites following the intervention, consistent with an epigenetic resilience profile in the CIITA gene, a gene related to immune response. Overall, these findings suggest that the intensive multimodal intervention induces favorable epigenetic changes associated with resilience, providing preliminary evidence that epigenetic biomarkers can reflect positive therapeutic responses in young people with a history of trauma.